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Hell architect igg1/27/2024 The presence or absence of anti-HAV IgG in the patient sample is determined by comparing the chemiluminescent signal in the reaction to the cutoff signal determined from an ARCHITECT HAVAB-G calibration. The resulting chemiluminescent reaction is measured as relative light units. Following another wash cycle, pre-trigger and trigger solutions are added to the reaction mixture. After washing, the acridinium-labeled antihuman IgG conjugate is added to bind to anti-HAV IgG. Anti-HAV IgG present in the patient sample binds to the HAV-coated microparticles. Patient's sample, assay diluent, and HAV-coated paramagnetic microparticles are combined first in a reaction well. The ARCHITECT HAVAB-G assay is an automated immunoassay designed for the qualitative detection of hepatitis A virus (HAV)-specific IgG antibody in human serum using chemiluminescent microparticle immunoassay method. HAV-specific IgG antibody (anti-HAV IgG) level in serum rises quickly once the virus is cleared and may persist for many years. HAV-specific IgM antibody level in serum usually falls to an undetectable level by 6 months after acute infection. In most cases of acute viral hepatitis A, IgM antibodies to HAV (anti-HAV IgM) are detectable by the time symptoms occur, usually 15 to 45 days after exposure. There is little or no evidence of transplacental transmission from mother to fetus or transmission to newborn during delivery. ![]() Viral spread by parenteral routes (eg, exposure to blood) is possible, but rare, because infected individuals are viremic for a short period of time (usually <3 weeks). Outbreaks frequently occur in overcrowded situations and high-density institutions and centers, such as prisons and healthcare or daycare centers. The virus is transmitted primarily by the fecal-oral route and spread by close person-to-person contact as well as by food and waterborne epidemics. Hepatitis A virus (HAV) is endemic throughout the world, occurring most commonly in areas of poor hygiene and low socioeconomic conditions.
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